Amodiaquine-induced hepatitis. A report of seven cases
Larrey, D.; Castot, A.; Pëssayre, D.; Merigot, P.; Machayekhy, J.P.; Feldmann, G.; Lenoir, A.; Rueff, B.; Benhamou, J.P.
Annals of Internal Medicine 104(6): 801-803
1986
ISSN/ISBN: 0003-4819 PMID: 2871789 Document Number: 283372
Seven patients developed hepatitis after receiving amodiaquine for malaria prophylaxis for 4 to 15 weeks. Four patients had a minor form of hepatitis: jaundice was mild or absent, serum aminotransferase levels were moderately increased, and recovery was prompt. Three patients had a severe form: jaundice was intense, serum aminotransferase levels were markedly increased, jaundice persisted for 3 to 6 months, and liver tests were still abnormal 7 to 27 months after the onset of hepatitis. In two patients, serum aminotransferase levels increased promptly after readministration of the drug, which is consistent with an immunoallergic mechanism for amodiaquine-induced hepatitis.