Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage
Sugiyama, H.; Maeda, T.; Akira, S.; Kishimoto, S.
Journal of Immunology 136(8): 3092-3097
1986
ISSN/ISBN: 0022-1767 PMID: 3082980 Document Number: 282558
An Abelson virus-transformed murine pre-B cell line class-switched from mu to gamma 3 or gamma 2b at the pre-B stage during culture. A class-switch was mediated by the deletion mechanism of the intervening CH genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to gamma 2b production.
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