Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDF gamma) on gamma-specific mRNA in murine B cells

Jones, S.; Chen, Y.W.; Isakson, P.; Layton, J.; Pure, E.; Word, C.; Krammer, P.H.; Tucker, P.; Vitetta, E.S.; Jones, S; Chen, Y.W; Isakson, P; Layton, J; Pure, E; Word, C; Krammer, P.H; Tucker, P; Vitetta, E.S

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Effect of T cell-derived lymphokines containing B cell differentiation factor (s) for IgG (BCDF gamma) on gamma-specific mRNA in murine B cells

Jones, S.; Chen, Y.W.; Isakson, P.; Layton, J.; Pure, E.; Word, C.; Krammer, P.H.; Tucker, P.; Vitetta, E.S.

Journal of Immunology 131(6): 3049-3051

1983

ISSN/ISBN: 0022-1767

PMID: 6605997

Document Number: 214273

Cytoplasmic RNA was isolated from cells cultured with LPS and LPS plus a T cell-derived supernatant (SN) (PK 7.1) containing B cell differentiation factors. The steady state levels of isotype-specific mRNA were assessed by Northern blot analysis with gamma-specific CH3 probes. It was demonstrated that the SN induces an increase in the level of mRNA for gamma 1 and a concomitant decrease in the levels of mRNA for gamma 2b and gamma 3.