Importance of the study of allergy and determination of the HLA group in the lipoid nephrosis in children. Study of 8 cases
Burguet, A.; Menget, A.; Bertrand, A.M.; Amsallem, D.; Brochot, J.L.; Burthey, M.E.; Fromentin, C.; Raffi, A.
Pediatrie 41(6): 461-468
1986
ISSN/ISBN: 0031-4021 PMID: 3808848 Document Number: 282226
Eight children with steroid-response nephrotic syndrome were investigated to study the relation-ship between steroid responsive syndrome, allergy and HLA-antigens. Six of them had clinical and/or biological allergic symptoms. The allergen was identified in four out of six cases (grass-pollen 2 cases, house dust 1 case, frullania 1 case). Six children had DR7 HLA-antigen, five had B12 antigen. Three of the four children with cortico-dependent nephrotic syndrome have associated B12-DR7 HLA antigens. Search of an allergen seems to be of interest in children with steroid-responsive nephrotic syndrome, since eviction of the allergen may be proposed as a complement to cortico-therapy.