Carcinoma in situ of the vulva. a clinicopathologic study of 50 cases
Powell, L.C.; Dinh, T.V.; Rajaraman, S.; Hannigan, E.V.; Dillard, E.A.; Yandell, R.B.; To, T.
Journal of Reproductive Medicine 31(9): 808-814
1986
ISSN/ISBN: 0024-7758 PMID: 3772899 Document Number: 281674
The authors reviewed 50 cases of carcinoma in situ of the vulva treated at the University of Texas Medical Branch, Galveston, from 1975 to 1984. Sixty-two percent of the patients were premenopausal. The most frequent complaint was vulvar itching. Twenty-six percent of the patients were asymptomatic. Recurrences were frequent (25%) and were associated with multifocal lesions, involved surgical margins and the bowenoid histologic type. Superficially invasive carcinoma was detected in 8% of patients, mostly postmenopausal women with simplex histologic types. Immunohistochemical studies failed to detect papillomavirus- or herpesvirus-associated antigens in any of the cases. Follow-up of 48 patients from six months to ten years revealed no mortality from invasive cancer.