Effect of erythrocytes on the stability of prostacyclin in healthy subjects and patients with cerebral dyshemias
Gabrielian, E.S.; Akopov, S.E.; Tunian, I.S.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 86(9): 1340-1343
1986
ISSN/ISBN: 0044-4588 PMID: 3535319 Document Number: 280884
The authors studied the interaction between red blood cells (RBCs) and prostacycline (P) in normal subjects and patients with transient disorders of the cerebral circulation and cerebral stroke. RBCs accelerated P disintegration with the formation of inactive products, with the process being most accelerated in RBC aggregation. It has been found that hyperosmolarity of the medium and disoxygenation of RBCs increase their ability to break down P while lactacydosis decreases this ability. It has been also established that there is a greater proportion of people with a marked ability of RBCs to break down P among patients with cerebral dyshemias, particularly with cerebral stroke. This might be due to alterations in the conformation of the surface layers of RBCs in abnormal conditions.