EEG studies in rats to determine the threshold levels of chlorpromazine with respect to the state of vigilance
Bergschicker, R.; Just, A.
Biomedica Biochimica Acta 45(3): 401-412
1986
ISSN/ISBN: 0232-766X PMID: 3707557 Document Number: 280860
Taking into account the actual vigilance status of the animals (awake, drowsiness, slow-wave-sleep) we were able to show EEG changes at lower chlorpromazine levels (0.42 mumole/kg b.w., i.p.) in contrast to 1.4 mumole/kg b.w., i.p.) in the model "without considering the vigilance status". These changes were especially pronounced during the awake state.
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