Comparison of isotonic and hypertonic fluids in resuscitation from hypovolemic shock
Peters, R.M.; Shackford, S.R.; Hogan, J.S.; Cologne, J.B.
Surgery Gynecology and Obstetrics 163(3): 219-224
1986
ISSN/ISBN: 0039-6087 PMID: 3092381 Document Number: 280719
Hypertonic electrolyte solutions provide effective fluids for resuscitation of burn patients and concurrent replacement of hemorrhage. Infusion of mannitol has also been advocated as a means of increasing cardiac output in acutely ill patients. Pigs which were bled to one-third of their blood volume were used in this random study of resuscitation with Ringer's lactate solution (RL), hypertonic saline solution (HSL) and RL with mannitol added (HMR) to give the same osmolality as HSL. Smaller volumes of the hyposmolar solution than of RL restored blood pressure and cardiac output. RL and HSL restored and maintained cardiac output more effectively than HMR. At 24 hours, HSL maintained blood pressure most effectively.