Intravenous administration of hypertonic sodium chloride solution with dextran or isotonic sodium chloride solution for treatment of septic shock secondary to pyometra in dogs
Fantoni, D.T.; Auler Junior, J.O.; Futema, F.; Cortopassi, S.R.; Migliati, E.R.; Faustino, M.; de Oliveira, C.M.
Journal of the American Veterinary Medical Association 215(9): 1283-1287
1999
ISSN/ISBN: 0003-1488 PMID: 10553438 Document Number: 500661
The effects of i.v. administration of hypertonic saline (7.5% NaCl) solution with 6% dextran 70 (HSSD) or isotonic saline (0.9% NaCl) solution (ISS) were evaluated in 14 dogs with septic shock secondary to pyometra. Immediately before surgery, 7 dogs received HSSD (4 ml/kg body weight, i.v.) and 7 dogs received ISS (32 ml/kg, i.v.) during a 5-min period. Measurements of haemodynamic and oxygenation variables were obtained before and 5 and 20 min after administration of fluids. Mean arterial pressure (MAP) increased significantly 5 and 20 min after administration of HSSD, whereas ISS did not affect MAP. However, cardiac output, cardiac index and oxygen delivery increased and haematocrit decreased after both treatments. Oxygen consumption and extraction rate and degree of acidosis did not improve after either treatment. Intravenous administration of small volumes of HSSD to dogs with septic shock secondary to pyometra resulted in improvement of haemodynamic and oxygenation status. Although cardiac output, cardiac index and oxygen delivery improved after administration of a volume of ISS equal to 8 times that of HSSD, MAP increased to >80 mmHg only after treatment with HSSD. It is concluded that administration of HSSD may be an effective treatment for septic shock in dogs.