Proteinuria selectivity pattern and its relations to clinical and laboratory characteristics and response to treatment in nephrotic syndrome at the Department of Child Health, Hasan Sadikin General Hospital, Bandung
Effendi, J.; Widjaja, J.; Singadipoera, B.S.
Paediatrica Indonesiana 26(9-10): 195-204
1986
ISSN/ISBN: 0030-9311 PMID: 3808737 Document Number: 280521
Minimal Changes Nephrotic Syndrome is a histological diagnosis that necessarily should be assessed by microscopic examination from renal biopsy preparation. A non-traumatic examination that is able to describe that glomerular lesions as well as predict its prognosis is needed. Proteinuria selectivity is proved to be able to make a description of the glomerular condition as selective proteinuria is usually found in minimal glomerular lesions. This study was carried out to find out the proteinuria selectivity pattern in the nephrotic children and its relation to clinical and laboratory characteristics, along with its relation to the response of steroid treatment. Proteinuria selectivity test was performed on 31 nephrotic children. Additionally other clinical and laboratory characteristics were also determined. In this study 21 patients were found to have selective proteinuria and 10 patients were with non-selective proteinuria. There was no difference in age and sex between the two groups; however, those who were non-selective proteinuria patients were more frequently found to have hypertension, hematuria, increased creatinine and blood urea-N levels. Most of the selective proteinuria patients (95%) were initial responders whereas only 40% were found to be initial responders among the non-selective proteinuria patients. In condition where histological diagnosis could not be assessed yet, examination of proteinuria selectivity is an important tool for making an early diagnosis as well as for prediction of its prognosis.