Remissions and acute toxicity during accelerated fractionated irradiation of non-small-cell bronchial carcinoma
Von Rottkay, P.
Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft . 162(5): 300-307
1986
ISSN/ISBN: 0179-7158 PMID: 3715709 Document Number: 280322
Accelerated fractionation (total dose 66 Gy, single dose 1.8 to 2 Gy, 1 to 2 fractions daily, total treatment period 4 to 5.5 weeks) brings about more than 40% of complete remissions and more than 90% of objective remissions (assessed by radiology) of non-small cell bronchogenic carcinomas. Tumor-induced symptoms are improved in more than 90%. A treatment period of less than four weeks causes considerable acute (and persistent) oesophageal reactions. In case of a treatment period of more than five weeks there is no substantial increase of toxicity.