Effect of alkylating drugs on rat cerebellum
Maślińska, D.
Folia Histochemica et Cytobiologica 24(1): 47-52
1986
ISSN/ISBN: 0239-8508 PMID: 3721019 Document Number: 280258
Ultrastructual and histochemical studies were performed on Wistar rats treated during 6 days with Cyclophosphamide 50 mg/kg per day or Lomustine 20 mg/kg per day. Changes in cerebellum after both drugs were simlar. Most severe ultrastructural lesions were found in glia, mainly astroglia cells localized in perivascular area. Cytoplasma of these cells was on the large area devoid of organelles. Neurons were less affected but in Purkinje cells mild ultrastructural lesions were found. Increased activity of glucose-6-phosphatase and decreased of succinate dehydrogenase activity in these cells suggest that cytostatic treatment disturbed metabolism in the neurons.