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Tumor localization and biodistribution of 99mTc-muramylpolypeptide (MPP) in the rat

Schümichen, C.; Weiss, H.

Nuklearmedizin. Nuclear Medicine 25(1): 28-30

1986

ISSN/ISBN: 0029-5566
PMID: 3714507
Document Number: 280239
Muramylpolypeptide, extracted from Nocardia opaca bacteria and originally designed for immunotherapy of malignant tumors, proved to localize in malignant tumors, when labeled with 99mTc. In the tumor-bearing rat 99mTc-muramylpolypeptide (MPP) showed a fast turnover and optimum tumor to soft tissue ratios were obtained as early as between 30-60 min after application. The uptake mechanism in malignant tumors remains uncertain.

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