Cerebral infarction in a bilateral common carotid artery ligation model protected by radix Salviae miltiorrhizae
Kuang, P.G.; Pu, C.Q.; Liu, Z.; Yin, W.M.; Zhang, F.Y.; Liu, Y.N.
Journal of Traditional Chinese Medicine 6(2): 121-124
1986
ISSN/ISBN: 0255-2922 PMID: 3773560 Document Number: 280150
The effect of RSM on cerebral infarction was evaluated in 120 SD rats. Bilateral common carotid artery ligation was done in 86 animals, a sham operation was done in 34 animals. Half an hour before ligation 48 animals were given 10 gm kg of RSM; 38 animals were given the same volume of normal saline. Morbidity and mortality were recorded for five days. Of the saline-treated animals 57.9% (22/38) died, while 29.2% (14/48) of the animals treated with RSM died during the observation period. Of the 48 RSM-treated animals only 4 (8.5%) remained in a comatose-like state after operation and died without apparent recovery from anesthesia. The number was 11 (28.9%) in the saline-treated group (P < 0.05). Death of saline-treated rats most frequently occurred within the first 6 hours after the ligation (13.38); the incidence of death in the same postoperative period in RSM-treted animals was significantly less (3/48, P < 0.01). No sham-operated animals died. The authors concluded that RSM is beneficial in postischemic treatment of stroke.