Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils
Egawa, M.; Hashimoto, N.; Tobe, A.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 85(6): 487-492
1985
ISSN/ISBN: 0015-5691 PMID: 4029815 Document Number: 256338
Cerebral protective effect of MCI-2016 the mean survival time were 8.1 and 6.4 h, respectively. In these cases, some animals survived over 12 h, while no animals surviving > 12 h were observed in the control group. In this model, animals showed severe neurological symptoms. This tended to be depressed by the administration of MCI-2016 at a dose of 25 mg/kg, i.p., which was observed early after ligation. A cerebral metabolic activator, Ca-hopantenate, slightly increased the survival time at a dose of 100 mg/kg, i.p., and a cerebral vasodilator, ifenprodil, was not effective. Subsequently, consecutive administration of MCI-2016 at a dose of 25 and 50 mg/kg, p.o., was more effective than a single administration of MCI-2016 at each dose. The mechanism for the cerebral protective effect of MCI-2016 was discussed.