Effect of recombinant human interferon gamma and interleukin 2 on CFU-GM
Krumwieh, D.; Hermann, R.; Kurrle, R.; Seiler, F.R.
Behring Institute Mitteilungen 80: 59-63
1986
ISSN/ISBN: 0301-0457 PMID: 3092795 Document Number: 279953
Human bone marrow CFU-GM were cultured with rHu-GM-CSF and varying concentrations of rHu-gamma-IFN. Concentration-dependent suppression of CFU-GM precursors by gamma-IFN was demonstrated. This suppression was, in part, reversible by addition of rHu-IL-2. Reversal was also concentration-dependent. Both immune-regulatory T-cell mediators seem to act on a more primitive stage of committed progenitor cell development.
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