A mouse model to estimate the potency of the diphtheria component in combined vaccines
Kreeftenberg, J.G.; van der Gun, J.; Marsman, F.R.; van Asten, J.A.; Sekhuis, V.M.; Hendriksen, C.F.
Developments in Biological Standardization 64: 21-24
1986
ISSN/ISBN: 0301-5149 PMID: 2878846 Document Number: 279683
A mouse model is presented to estimate the potency of the diphtheria component in combined vaccines. In addition, a simplified mouse test is suggested for routine potency control of diphtheria. It will be important to discuss this approach to replace the lethal challenge test in guinea pigs.
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