Spatial organization of the N-terminal beta-endorphin tridecapeptide
Akhmedov, N.A.; Suleĭmanova, E.V.; Ibragimov, E.I.; Godzhaev, N.M.
Biofizika 31(4): 561-563
1986
ISSN/ISBN: 0006-3029 PMID: 2944544 Document Number: 279537
Using conformational analysis spatial structure and conformational properties of the N-terminal tridecapeptide--endorphine molecules were investigated. Calculations were based on the fragmental analysis using non-valent, electrostatic, torsional interactions and hydrogen bonds. It was shown that tridecapeptide could exist in several low-energetical conformational states. Enkephaline fragments structure depends on the most perspective structure of free metioninenkephaline. The results can be used for conformational analysis of endorphine molecules, for structure--function relations study.