Kinetics of the excretion of a membrane-active macroheterocycle from the body in mice
Plotnikova, E.K.; Golovenko, N.I.; Zin'kovskiĭ, V.G.; Luk'ianenko, N.G.; Zhuk, O.V.
Farmakologiia i Toksikologiia 49(4): 64-67
1986
ISSN/ISBN: 0014-8318 PMID: 3758332 Document Number: 279508
The study of the excretion kinetics of N-(3H-aminoacetyl)-I-aza-4,7,10,13-tetraoxacyclopentadecane hydrochloride and its metabolites with the mouse urine and feces showed a high relative effectiveness of the urinary excretion (only some 2% of the dose is excreted with the feces). It was also found that there occurs an intensive biotransformation of the compound yielding free and water-soluble metabolites.
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