The kinetics of the urinary excretion of mexidol and its glucuronate conjugate in patients
Sariev, A.K.; Zherdev, V.P.; Litvin, A.A.; Kolyvanov, G.B.; Neznamov, G.G.; Petrova, T.N.; Davydova, I.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 62(5): 42-46
1999
ISSN/ISBN: 0869-2092 PMID: 10572752 Document Number: 7830
Using HPLC with fluorescence detector we studied elimination kinetics of the antioxidant drug mexidol and its glucuronoconjugated metabolite in 16 patients suffering from neurosis and traumatic CNS injury after receiving mexadol (in a dose of 500 mg, in tablets). It is found that mexidol undergoes rapid glucuronoconjugation and is excreted with urine (0.31% and 49.6% of the received dose in the form of mexidol and its glucuronoconjugate, respectively) within 11.5-h period of examination. A substantial variability in the rate and degree of mexidol and glucuronoconjugate elimination with urine is observed. A trend to intensive glucuronoconjugation is observed in patients aged up to 40.
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