50-grams glucose challenge test for screening of gestational diabetes mellitus in high risk pregnancy
Juntarat, W.; Rueangchainikhom, W.; Promas, S.
Journal of the Medical Association of Thailand 90(4): 617-623
2007
ISSN/ISBN: 0125-2208 PMID: 17487113 Document Number: 2795
Objective: To evaluate the cutoff value of the 1-hr 50-gram glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM), in high-risk pregnancy, and to determine the prevalence of GDM in this group.Study design: Descriptive study (Diagnostic test).Subjects: Eight hundred and thirty-eight pregnant women, 24-28 weeks, were identified and recruited based on risk indicators between January and October 2004.Material and Method. A GCT was performed in this group. All women with plasma glucose value >= 130 mg/dl were given a 3-hr, 100-gram glucose tolerance test (OGTT) to diagnose gestational diabetes mellitus using Carpenter and Coustan diagnostic criteria. The receiver-operator characteristic (ROC) curve was used to identify the cut-off value of GCTfor detecting GDM Main outcome measures: The cut-off value of GCT for detecting GDM by using ROC curve with the sensitivity and specificity of various cut-off values.Results: The ROC curve identified a GCT value of >= 140 mg/dl as the cut-off value for detecting GDM, which showed the sensitivity and specificity of 95.3% and 48.6% respectively. The prevalence of GDM in high-risk pregnant women was 20.17% (169/838).Conclusions: Recommended threshold of 140 mg/dl used as the cut-off value of 50-gram, I-hr GCTfor screening GDM in high-risk pregnancy.
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