Calcium antagonists in the prevention of motion sickness
Lee, J.A.; Watson, L.A.; Boothby, G.
Aviation Space and Environmental Medicine 57(1): 45-48
1986
ISSN/ISBN: 0095-6562 PMID: 3510617 Document Number: 279452
Flunarizine is a calcium antagonist which has proved clinically useful in controlling chronic vertigo. In a double blind crossover trial 10 subjects were used to compare the electronystagmic responses to motion in patients taking flunarizine, prochlorperazine maleate, or placebo. Flunarizine is shown to be a powerful peripherally acting labyrinthine suppressant, with application in the prevention of motion sickness. Flunarizine produces none of the central depressive side effects characteristic of antihistamines and anticholinergics, which are the conventional anti-motion sickness drugs.