Changes in renal function on response to rapid administration of cisplatinum
Mikata, N.; Suzuki, M.; Takeuchi, T.; Kunisawa, Y.; Fukutani, K.; Kawabe, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 13(3 Pt 1): 508-513
1986
ISSN/ISBN: 0385-0684 PMID: 3954374 Document Number: 279349
Seven patients with urologic carcinomas were examined for changes in renal function as a result of administration of Cisplatinum (CDDP) at a high rate of 50 or 100 mg/m2 within 5 hours, superimposing 2 liters of fluid before and after the CDDP dose, and the results were compared with the pretreatment values. Renal function tests revealed that BUN was elevated to 20 mg/dl or more in 5 but not beyond 30 mg/dl in any of the patients, that serum creatinine was elevated to 1.4 mg/dl or more in 3 cases with a maximum of 1.5 mg/dl, and that Ccr was decreased to less than 70% of the pretreatment value in 3 patients. These manifestations of imparied renal function were all transient and reversible, being mostly restored to the pretreatment values during or within 1 month after the end of CDDP treatment, and did not necessitate the discontinuation of the treatment in any patients. The above findings proved the rapid infusion of CDDP to be as safe in terms of renal function as prolonged, continued i.v. infusion of the drug, which would these fore make CDDP treatment of outpatients possible.