Therapy of atopic dermatitis in children. Study on the use of a desensitizing preparation
Paci, A.; Taddeucci-Brunelli, G.; Barachini, P.; Magliaccio, P.; Pierini, G.; Crimaldi, G.
La Pediatria Medica e Chirurgica Medical and Surgical Pediatrics 8(6): 839-844
1986
ISSN/ISBN: 0391-5387 PMID: 2440012 Document Number: 279098
Children with Atopic Dermatitis have been treated with Histaglobin (gamma globulin + histamine) applied by hypodermic injections. The patients (42) were divided into three groups: the first one (ten cases) aged between 9 and 5 years; the second one (eight cases) between 5 and 2 years and the third one (twenty four cases) aged less than two years. The trial has been carried out in two phases: the first one consisted of nine injections with increasing doses ranging from 1/3 to 1 ampoule with 4-6 day intervals; the second one, "the maintenance period", was made by nine injections of 1 ampoule with increasing intervals from two up to four weeks. The following four parameters were checked along all the therapy period: prurigo, erythema, exudation, scratching lesions. All the listed symptoms have been observed to decrease of intensity mainly during the first phase, until the complete disappearance of some of them; the residual symptoms continued to have a further improvement during the second phase; in most case disappeared completely. Absolutely no troubles of any kind have been noticed. Consequently the Authors consider the desensitization therapy by Histaglobin on the whole satisfying.