Clonidine and enphenamic acid interaction study in dogs
Dalvi, S.S.; Kshirsagar, N.A.; Satoskar, R.S.
Archives Internationales de Pharmacodynamie et de Therapie 280(1): 106-116
1986
ISSN/ISBN: 0003-9780 PMID: 2872861 Document Number: 278862
The drug interaction between clonidine (Cl) and enphenamic acid (En.A.), a newer non-steroidal anti-inflammatory drug (NSAID) was studied in anaesthesized dogs. Prior administration of En.A. in animals modified the blood pressure response to clonidine. Thus En.A., administered 1 hr before clonidine, potentiated the hypertensive response and blocked the subsequent hypotensive response to clonidine. Intracerebroventricular administration of En.A. did not affect the usual blood pressure response to clonidine. Similarly, this interaction was not observed in reserpinized animals and it was only partially blocked in normal dogs, treated with tolazoline. It is concluded that En.A. interferes with blood pressure responses to clonidine and that this interaction is probably of a peripheral, vascular, nature.