Biological aspects of chronic lymphoid leukemia
Binet, J.L.; Travade, P.; Chastang, C.; Dighiero, G.; Merle-Béral, H.; Raphael, M.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 180(5): 503-511
1986
ISSN/ISBN: 0037-9026 PMID: 2950973 Document Number: 278832
The present study is concerned with clinical prognostic classifications of chronic lymphocytic leukemia derived from numerous statistics and multivariate survival analysis. We analyse the prognostic significance of some biological patterns: bone marrow histological studies, lymph node biopsies, size, structure and doubling time of blood lymphocytes, tumoral markers and karyotype analysis. The problem of the monoclonal clone origin is discussed: differentiation abnormality or proliferation of a physiological clone.