Prostaglandin synthetase activity in the different layers of the kidneys of young rats exposed to polyene antibiotics
Efendiev, A.M.; Pomoĭnetskiĭ, V.D.; Kubatiev, A.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(3): 302-304
1986
ISSN/ISBN: 0365-9615 PMID: 3082383 Document Number: 277967
Prostaglandin (PG)-synthestase activity was studied in the cortical, medullary and papillary kidney layers in young rats subjected to prolonged administration of polyene antibiotics (amphotericin B, levorin and nystatin). This activity was markedly increased during the first few hours after the administration of amphotericin B. At later terms a pronounced decline in the enzyme activity was observed. The changes were most prominent in the medullary and papillary layers. The other two antibiotics were less potent. The experimental results have shown that amphotericin B had maximal effect on renal PG-synthetase activity, while the sodium salt of nystatin was least effective.