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Comparative thermal properties of the monohydrates of sodium theophylline and theophylline

Serajuddin, A.T.

Journal of Pharmacy and Pharmacology 38(2): 93-96

1986

ISSN/ISBN: 0022-3573
PMID: 2870169
Document Number: 277555
The thermal properties of sodium theophylline monohydrate, as determined by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and hot stage microscopy, were studied and compared with those of theophylline monohydrate. The onset of dehydration of sodium theophylline monohydrate varied between 170 and 264.degree. C depending on the atmospheric conditions surrounding the sample. Under similar conditions, dehydration of theophylline monohydrate occurred at 18 to 65.degree. C. Sodium theophylline melted with the onset of a DSC endotherm at 391.degree. C. Possible effects of the physicochemical properties of sodium theophylline monohydrate on its dosage forms and the expected superiority of the sodium salt over theophylline and aminophylline are discussed.

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