Alteration of guinea pig erythrocyte superoxide dismutase activity by dietary antioxidants
Omaye, S.T.; Potter, B.D.; Poovaiah, B.P.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 56(2): 161-164
1986
ISSN/ISBN: 0300-9831 PMID: 3733337 Document Number: 277322
An improved method for the measurement of superoxide dismutase (SOD) activity in guinea pig erythrocytes was developed. Alteration of guinea pig erythrocytes superoxide dismutase activity by the dietary antioxidants ascorbic acid and selenium was investigated. Erythrocyte SOD activity was directly related to the ascorbic acid intake of guinea pigs fed 0.05 ppm of selenium. Dietary levels of ascorbic acid were 0.200 and 400 mg/kg. In guniea pigs fed 0.20 ppm of selenium, there was an increase in superoxide dismutase activity only in the group of animals fed the 400 mg ascorbic acid/kg of diet. Results suggest that substantial protection from deleterious .**GRAPHIC**. can be provided by changes in dietary ascorbic acid.