Results of splenectomy with polychemotherapy in the treatment of 15 chronic myeloid leukemia patients
Mendeleev, I.M.; Berliner, G.B.; Miasnikov, A.A.; Polezheav, I.N.
Terapevticheskii Arkhiv 58(9): 84-88
1986
ISSN/ISBN: 0040-3660 PMID: 3466393 Document Number: 277095
The results of splenectomy followed by chemotherapy are analysed. Fifteen patients with chronic myeloid leukemia (CML) were entered into the study. The maximal survival of one of the patients subjected to splenectomy was 102 months. The authors come to the conclusion that it is desirable that CML patients should be subjected to splenectomy after preliminary preparation (chemotherapy and chemoprotectors) at the early stages of the illness, which is to be followed by monochemotherapy. Provided the latter is unsuccessful, the change over to polychemotherapy similar to the treatment protocols for myeloid leukemia is suggested.