Adult T-cell leukemia and non-Hodgkin's lymphoma in brothers
Maekawa, I.; Kawamura, T.; Miyake, T.
Hokkaido Journal of Medical Science 61(1): 146-151
1986
ISSN/ISBN: 0367-6102 PMID: 2870968 Document Number: 277014
Adult T-cell leukemia/lymphoma (ATL) is an endemic disease in the Southwestern districts of Japan. Intrafamilial cluster of ATL and other T-malignancy frequently reported in these area. We reported cases of ATL and non-Hodgkin's lymphoma in brothers, they were born in Hokkaido where is non-endemic area of ATL. The first case (ATL) is 53 y. male and the second case (non-HD), younger brother of the first case, is 55 y male. Anti-ATLA (ATL-virus associated antigen) antibody were positive in both of them, their elder sister, wife and child of the first cases. Examination of anti-ATLA antibody and follow up study is necessary in the family members of ATL, because they may be in a high risk group of ATL outbreak.