Secretion of antidiuretic hormone and renal function during the awakening of Jaculus orientalis from hibernation
Baddouri, K.; el Hilali, M.
Journal de Physiologie 81(3): 202-208
1986
ISSN/ISBN: 0021-7948 PMID: 3795117 Document Number: 276556
Chemical analysis of kidney tissue from jerboa (Jaculus orientalis) during hibernation shows that the cortico-papillary gradient of Na+ ions is strongly reduced, whereas that of urea is completely suppressed. During the spontaneous rise in body temperature which occurs as the animal comes out of hibernation, the accumulation of Na+ in the papilla then in the medullary zones begins to increase from 25-30 degrees C body temperature, before the appearance of a urea gradient. This confirms the hypothesis that urea accumulation in the kidney medulla is coupled to active transport of sodium. This active transport may be partially dependent upon circulating ADH, circulating levels of which increase with increasing body temperature. Glomerular filtration in normothermic jaculus orientalis is 696 +/- 155 microliter . min-1 and urinary flow is relatively low in this desert species at 1.12 +/- 0.18 microliter . min-1. During hibernation at a body temperature between 7 and 8 degrees C glomerular filtration and urinary flow are not measurable. Glomerular filtration appears (51 microliter . min-1 at 26 degrees C) and increases at a temperature range where systemic blood pressure has already attained a normal level. This indicates that the reestablishment of glomerular filtration may be linked to intra-renal vasomotor events as is suggested by measurement of plasma renin activity during the coming out of hibernation.