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Intraocular penetration of new antiviral agent, hydroxyacyclovir (BW-B759U)

Schulman, J.; Peyman, G.A.; Horton, M.B.; Liu, J.; Barber, J.C.; Fiscella, R.; de Miranda, P.

Japanese Journal of Ophthalmology 30(1): 116-124

1986

ISSN/ISBN: 0021-5155
PMID: 3014189
Document Number: 276431
9-[(2-hydroxyl-1-(hydroxymethyl)ethoxy]methyl)guanine (hydroxyacyclovir) is a nucleoside analogue with a high degree of efficacy against herpes simplex virus types 1 and 2 and cytomegalovirus (CMV). This antiviral agent demonstrates a low toxicity towards uninfected cells. Intraocular levels in rabbits were evaluated following subconjunctival, intravenous, intravitreal and topical administration. Retinal toxicity studies were performed. Hydroxyacyclovir may have applications in the treatment of deep herpetic infections, CMV retinitis, and acute retinal necrosis.

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Takahashi, T. 1971: Intraocular penetration of kanendomycin. II. Subconjunctival injection Nippon Ganka Gakkai Zasshi 75(1): 7-12
Broughton, W.; Goldman, J.N. 1973: The intraocular penetration of chloramphenicol succinate in rabbits Annals of Ophthalmology 5(1): 71
Kaswan, R.L. 1988: Intraocular penetration of topically applied cyclosporine Transplantation Proceedings 20(2 Suppl 2: 650-655
Mounier, M.; Adenis, J.P.; Denis, F. 1988: Intraocular penetration of ciprofloxacin after infusion and oral administration Pathologie-Biologie 36(5 Part 2): 724-727
Kikuchi, H.; Ohtsuki, K. 1977: Intraocular penetration of sodium fluorescein administered retrobulbarly Nippon Ganka Gakkai Zasshi 81(7): 861-871
Sugihara, I.; Ueda, K.; Saiki, H.; Hanada, M.; Doi, H.; Ishibashi, T.; Nakayama, M.; Numa, R.; Yamauchi, K.; Kawata, R. 1990: Comparison of intraocular penetration level of cefuzonam sodium and cefotiam after intravenous and subconjunctival injection Nippon Ganka Gakkai Zasshi 94(2): 211-218
Mack, J.E. 1988: Ribavirin: an antiviral agent with promise Pediatric Nursing 14(3): 220-221
Kikuchi, H.; Ohtsuki, K. 1979: Intraocular penetration of sodium fluorescein administered locally. (Topical instillation, subconjunctival infection and sub-Tenon's capsular injection) Nippon Ganka Gakkai Zasshi 83(11): 2045-2054
Galegov, G.A.; Litvin, A.A. 2007: Panavir, as a broad spectrum antiviral agent Antibiotiki i Khimioterapiia 52(9-10): 45-49
Inglot, A.D. 1980: Interferon as an antiviral, antineoplastic and immunomodulating agent Postepy Higieny i Medycyny Doswiadczalnej 34(2): 89-105
Bergogne-Bérézin, E.; Berthelot, G.; Kafé, H.P.; Dournovo, P. 1985: Influence of a fluidifying agent (bromhexine) on the penetration of antibiotics into respiratory secretions International Journal of Clinical Pharmacology Research 5(5): 341-344
2003: New antiviral agent. Hepatitis B therapy with slight resistance risk MMWFortschrittederMedizin 145(51-52): 40
Peteri, D.; Sterner, W. 1973: Chemistry and toxicology of a new antiviral agent: N-(1-adamantyl)-2-(2-dimethylamino-ethoxy)-acetamide-HCl.1 Arzneimittel-Forschung 23(4): 577-581
Bergogne-Berezin, E.; Pierre, J.; Dournovo, P. 1979: Experimental study of the possible influence of a fluidifying agent (bromhexine) on the penetration of erythromycine into bronchial secretions Therapie 34(6): 705-711
Loginova, S.I.; Borisevich, S.V.; Koval'chuk, A.V.; Shtabnaia, V.V.; Pashchenko, I.I.; Khamitov, R.A.; Maksimov, V.A. 2007: The in vitro antiviral activity against the causative agent of hemorrhagic fever with renal syndrome Voprosy Virusologii 52(4): 34-36
So, E.C.; Huang, S.T.; Sum, D.C.; Tan, P.P. 1988: Atracurium used as a pretreatment agent to inhibit succinylcholine induced increased intraocular pressure Ma Zui Xue Za Zhi 26(4): 387-390
Ikeda, N.; Saito, T.; Hayasaka, S.; Hayasaka, Y. 2001: Unilateral symptomatic elevation of intraocular pressure and prevention using a hyperosmotic agent during hemodialysis Japanese Journal of Ophthalmology 45(6): 659-661
Aksenov, V.A.; Selidovkin, D.A.; Gladkikh, G.N.; Grakhova, A.G.; Bogdanova, N.S. 1970: Evaluation of the preventive effectiveness in influenza of the new native antiviral chemical agent oxoline in the 1969 epidemics Farmakologiia i Toksikologiia 33(6): 726-733
Ray, S.S.; Thomas, A. 1977: Intravenous glycerol-sodium ascorbate combination as osmotic agent to reduce intraocular pressure Indian Journal of Ophthalmology 25(2): 27-30
Amlacher, R. 1985: Route-dependent different relations between acute and subacute toxicity of the potential antiviral agent benzoxazolyl-2-formyl-S-ethyl-isothiosemicarbazone in mice Die Pharmazie 40(2): 132-133