Evaluation of active specific immunization against paraquat toxicity in rats

Cadot, R.; Descotes, J.; Cuilleron, C.Y.; Grenot, C.; Evreux, J.C.; Cadot, R; Descotes, J; Cuilleron, C.Y; Grenot, C; Evreux, J.C

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Evaluation of active specific immunization against paraquat toxicity in rats

Cadot, R.; Descotes, J.; Cuilleron, C.Y.; Grenot, C.; Evreux, J.C.

Veterinary and Human Toxicology 28(3): 226-229

1986

ISSN/ISBN: 0145-6296

PMID: 3727354

Document Number: 276117

Four groups of Wistar rats were immunized against a BSA-paraquat derivative antigen, when lethally poisoned with paraquat dichloride via intraperitoneal route. No significant correlation in survival rate was observed between immunized (5/45) and control (0/26) rats, but a significant correlation (p less than 0.05) in the mean survival time was noted in immunized rats as compared to controls (9.1 +/- 16.8 days and 2.0 +/- 0.8 days versus 2.1 +/- 2.4 days and 1.0 +/- 0.1 days respectively).