Effects of morphine, buprenorphine with and without diazepam on hemodynamic changes in dogs with acute coronary arterial occlusion
Sone, T.; Kato, T.; Yamamoto, M.; Sakamoto, K.; Tanaka, S.; Iida, H.; Harada, T.; Tanahashi, T.
Masui. Japanese Journal of Anesthesiology 35(8): 1199-1206
1986
ISSN/ISBN: 0021-4892 PMID: 3783912 Document Number: 275437
Effects of clinical doses of morphine (0.25 mg/kg) and buprenorphine (10 .mu.g/kg) alone, and the combination with diazepam (0.3 mg/kg) on the hemodynamics were studied comparatively in dogs with acute coronary arterial occlusion. Buprenorphine slightly decreased cardiac output (-10%), due to bradycardia, but no change was observed by morphine. With the combined use of diazepam, there was a similar decrease in heart rates and mean arterial pressure, but the changes in cardiac output were the same with the single use group. Pulmonary vascular resistance increased by morphine with diazepam. Myocardial oxygen balance was not affected by both drugs and those with diazepam, because myocardial oxygen extraction ratio did not change through the experiment, while coronary blood flow decreased with the combined use of diazepam. In conclusion, single use of morphine and buprenorphine, and combined use with diazepam do not cause significant depression of the hemodynamics, even in the situation where cardiac reserve is compromised.