The systemic and coronary hemodynamic effects of intracoronary arterial tolazoline (Priscoline)
Rowe, G.G.; Zarnstorff, W.C.; Afonso, S.
Archives Internationales de Pharmacodynamie et de Therapie 230(1): 131-139
1977
ISSN/ISBN: 0003-9780 PMID: 603303 Document Number: 112026
Intracoronary injection of tolazoline in dogs produces transient coronary vasodilatation with marked reduction in the arteriovenous oxygen difference and little change in myocardial oxygen consumption. At lower doses coronary effects are produced almost exclusively but as the dose increases, systemic cardiovascular changes occur also. No fatalities occurred even with large doses of tolazoline into the coronary arteries of these healthy dogs. Since intraarterial tolazoline is used to improve visualization of vascular beds in other portions of the body, its possible use for coronary arteriography is discussed.