Stable ascorbic acid solution for parenteral use
Ciminera, J.L.; Wilcox, P.W.
Journal of the American Pharmaceutical Association. American Pharmaceutical Association 35(12): 363-365
1946
PMID: 20283122 Document Number: 2752
The preparation of a stable buffered solution of ascorbic acid suitable for parenteral administration is described. Trisodium phosphate is used to buffer the solution at pH 6.0 to 6.5. Manufacture and storage are done in an atmosphere of nitrogen to prevent oxidation. Sterilization is accomplished by heating sealed ampuls for ten minutes at 100°. This is made possible by filling into small-size ampuls (2 cc.) and by incorporating phenol in a concentration of 0.5 per cent.
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