Human papillomavirus deoxyribonucleic acid in adenocarcinoma and adenosquamous carcinoma of the uterine cervix
Smotkin, D.; Berek, J.S.; Fu, Y.S.; Hacker, N.F.; Major, F.J.; Wettstein, F.O.
Obstetrics and Gynecology 68(2): 241-244
1986
ISSN/ISBN: 0029-7844 PMID: 3016624 Document Number: 274497
This report describes the detection of human papillomavirus type 16 or 18 deoxyribonucleic acid (DNA) in nine of 15 invasive tumors of the cervix, including three squamous carcinomas, four adenosquamous carcinomas, one glassy cell carcinoma, and one adenocarcinoma. The viral DNA was identified by Southern blotting and DNA hybridization. Human papillomaviruses may play an etiologic role in the development of at least some adenocarcinomas and adenosquamous carcinomas as well as most squamous tumors of the cervix.