Use of lipid microspheres as a drug carrier for antitumour drugs
Mizushima, Y.; Shoji, Y.; Kato, T.; Fukushima, M.; Kurozumi, S.
Journal of Pharmacy and Pharmacology 38(2): 132-134
1986
ISSN/ISBN: 0022-3573 PMID: 2870158 Document Number: 274185
9-Oxo-15-hydroxy-.DELTA.7,10,13-prostatrienoic acid methyl ester (.DELTA.7-PGA1), an antitumour drug was incorporated into lipid microspheres of 0.2 .mu.m diameter (lipo-.DELTA.7-PGA1). In in vivo experiments, lipo-.DELTA.7-PGA1 had a significantly greater antitumour activity than free .DELTA.7-PGA1 against P388 leukemia, Lipo-.DELTA.7-PGA1 slightly, but significantly prolonged the survival time of mice inoculated with L1210 leukemia, whereas free .DELTA.7-PGA1 did not. Against MM46 ascites tumour, the survival time after treatment with 10 mg kg-1 of lipo-.DELTA.7-PGA1 was significantly greater than that after the same dose of free .DELTA.7-PGA1. The results suggest that lipid microspheres can be used as drug delivery carriers for lipid soluble antitumour agents.