Effect of ascorbic acid in the presence of neomycin on isolated rat stomach strips
Korolkiewicz, Z.; Poćwiardowska-Ciara, E.
Acta Physiologica Polonica 37(4-5): 177-182
1986
ISSN/ISBN: 0044-6033 PMID: 3591360 Document Number: 273966
The effects of vitamin C and acetylcholine on the smooth muscle of rat stomach were compared after neomycin-induced blockade of phosphatidylinositol metabolism. The cumulative curves of dose-dependent responses showed a non-competitive antagonism between vitamin C and neomycin. On the other hand, the antagonism between acetylcholine and neomycin was of a mixed, competitive-non-competitive type. The results of the experiments suggest the conclusion that a normal metabolism of phosphatidylinositol controlling calcium transport into the cells is necessary for the stimulating effect of vitamin C on the contractions of the smooth muscles in the digestive tract.