Genetic toxicology evaluation of the novel semi-synthetic antibiotic piperacillin
Cheng, M.; Manandhar, M.; Iatropoulos, M.J.; Noble, J.F.
Arzneimittel-Forschung 36(9): 1379-1383
1986
ISSN/ISBN: 0004-4172 PMID: 3539126 Document Number: 272861
Piperacillin (T-1220, Pipracil) a semi-synthetic antibiotic was evaluated in a battery of genetic toxicology assays. The assays employed were: the microbial assay, the host mediated assay, the microbial assay incorporating urine samples from mice dosed with piperacillin, the in vivo cytogenetic assay, and the dominant lethal assay. In all assays, piperacillin produced consistent negative results indicating that piperacillin does not have mutagenic potential.
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