Calcium induced potassium efflux in erythrocytes of marine teleosts
Marino, D.; Marino, M.T.; Bolis, L.; Milhaud, G.
Biomedicine and PharmacoTherapy 40(9): 345-348
1986
ISSN/ISBN: 0753-3322 PMID: 3103705 Document Number: 272765
The effect of the calcium-ionophore A23187 + Ca++ on the K+ transport in the intact erythrocytes of seawater fishes was investigated. A23187 + Ca++ induced a significant increase in the cell-membrane permeability for potassium ion, while A23187 + Mg++ was ineffective. Addition of EGTA to the medium blocked the ionophore + Ca++ effect. Quinidine inhibited the A23187 + Ca++-induced K+ transport in the nucleated fish red cell. Propranolol is effective in the fish RBC in the presence of Ca++ and EGTA. The relationship of the calcium-induced alkali cation transport in nucleated red cell to that in human red cell is discussed.