Protein a and acid alpha-1-glycoprotein as factors discriminating immunoglobulins G in children suffering from leukemias
Wróblewski, Z.; Mejbaum-Katzenellenbogen, W.; Halikowski, B.
Archivum Immunologiae et Therapiae Experimentalis 34(1): 85-91
1986
ISSN/ISBN: 0004-069X PMID: 3465281 Document Number: 272743
The studies on IgG-3 subclass in the course of acute lymphoblastic leukemia (ALL) in children were performed. The presence of this IgG subclass was not shown, using chromatography on AGP-Sepharose for its isolation and Protein A-Sepharose for its identification. The possibilities of excretion of this IgG subclass with urine and proteolytic digestion in neutral pH by serum enzymes were excluded. Acid alpha-1-glycoprotein (AGP) isolated from serum of children with ALL interacts with IgG-3 of normal serum.