Clinical study of the beta-blocker chlorpropanol (tobanum) in hypertension patients
Sirakova, V.; Penkov, N.; Kaponov, K.
Vutreshni Bolesti 25(1): 35-41
1986
ISSN/ISBN: 0506-2772 PMID: 2872751 Document Number: 272369
The antihypertensive effect and tolerance of chlorpropanol was determined in 30 patients with hypertonic disease. The treatment was carried out only with tobanum as an open experiment with a dose from 10 to 30 mg. Before and towards the end of the treatment, the following indices were calculated from the simultaneous record of M-echocardiogram of left ventricle, ACG, PhCG and ECG: stroke volume (SV), minute volume (MV) cardiac index (CI), ejection fraction (EF), mean velocity of circumferential fibres shortening (Vcf), and peripheral vascular resistance (PVR). Chlorpropanol normalized the pressure in 83.3% of the treated, reducing the systolic pressure with 14.9%, and the diastolic--with 15.1%. The reduction of the pressure in hyperkinetic type of circulation is associated with the reduction of CI (p less than 0.05) as result from the slowed down cardiac rate (p less than 0.001), in hypokinetic type--with the reduction of PVR (p less than 0.05), and in eukinetic--with the normalization of the ratio between those two parameters. EF was not changed during the treatment, Vcf was reduced (p less than 0.045), but remained within the physiological limits. Chlorpropanol is with pronounced negative chronotropic effect. It has a good tolerance.