Kinetics of the formation of AT-specific DNA-distamin complex
Sizova, I.A.; Poletaev, A.I.
Biofizika 31(5): 768-770
1986
ISSN/ISBN: 0006-3029 PMID: 3778954 Document Number: 272002
Kinetics of DNA--distamin complex formation was studied by means of the stop-flow method. It has been found that the binding reaction is much faster than in the case with distamycin A and has only two stages. The differences in kinetic properties of the complexes of distamin and distamycin A with DNA has been interpreted as resulting from the formation of different bonds by protonated positively charged N-containing groups of ligands with negatively charged DNA phosphates.