Effect of somatostatin on hypercalcemia stimulated gastric juice and exocrine pancreas secretion in the human
Lenz, T.; Kölbel, C.; Herzog, P.; Holtermüller, K.H.
Zeitschrift für Gastroenterologie 24(2): 74-79
1986
ISSN/ISBN: 0044-2771 PMID: 2870592 Document Number: 271897
Hypercalcemia produced in healthy volunteers by intravenous infusions of calciumgluconolactobionate increased outputs of gastric acid, pepsin, and pancreatic enzymes. Hypercalcemia did not affect gallbladder emptying and serum gastrin values. Further, intravenous somatostatin (SRIF, 5 micrograms/kg.h) markedly inhibited secretion of gastric acid (p less than 0.01), pepsin (p less than 0.05), and pancreatic enzymes (p less than 0.02) stimulated by hypercalcemia. SRIF-inhibited outputs were below basal values. These results indicate that the inhibitory effect of SRIF on exocrine cells of the human gastrointestinal tract can not be reversed by extracellular hypercalcemia.