Thyroidectomy for life threatening giant familial goitre
Huizinga, W.K.; Chadwick, S.J.; Jialal, I.; Desai, R.K.
Tropical and Geographical Medicine 38(1): 96-100
1986
ISSN/ISBN: 0041-3232 PMID: 3961917 Document Number: 271838
Urgent thyroidectomy for giant multinodular goitre causing airway obstruction was necessary in the mater familias of a family with a high prevalence of non-endemic goitre. Post operative complications are briefly discussed. Family screening revealed a 100% incidence of nodular goitre in eight first generation descendants with hyperthyroidism in one. A euthyroid pattern was found in 6 of these, as well as in 5 of 19 second generation descendants tested. In two of the first generation descendants dyshormonogenesis was excluded as an aetiological factor by the perchlorate discharge test.