Comparative analysis of the surface antigens of transplantable melanomas in hamsters. II. Examination of serologic reactivity of sera with isolated melanocytes by the cross-reaction and absorption test
Kozłowska, K.; Zurawska-Czupa, B.; Kostulak, A.
Archivum Immunologiae et Therapiae Experimentalis 34(5-6): 595-605
1986
ISSN/ISBN: 0004-069X PMID: 3296998 Document Number: 270702
The reactivity of sera of hamsters bearing melanotic and amelanotic melanoma with isolated melanocytes was evaluated using immunoadherence test and cross-reactions. Besides, the ability of neoplastic melanocytes to absorption of antibodies from these sera, was tested. The reactivity of cells of both melanomas with serum of hamsters bearing the original type.sbd.melanotic melanoma.sbd.appeared the same and twice as high in amelanotic cells with serum of animals being amelanotic melanoma. This suggests that in the course of spontaneous alteration, the new form.sbd.amelanotic, does not lose the original antigens but acquires new ones, not present on the melanotic cells. The above findings were confirmed by the absorption test.