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Specific impairment of ADP-induced platelet aggregation by cannabinoids

Nathan, I.; Dvilansky, A.; Lazarowitz, J.; Lander, N.; Livne, A.

International Journal of Tissue Reactions 8(3): 193-198

1986

ISSN/ISBN: 0250-0868
PMID: 3781759
Document Number: 268761
The structure-activity relationship of the inhibition of ADP-induced platelet aggregation by cannabinoids was studied. A marked specificity was revealed: derivatives in which the two asymmetric centers have a configuration opposite to that of the natural cannabinoids and have a dimethylheptyl (DMH) side-chain were most inhibitory. It is concluded that the mode of inhibition includes a specific interaction of the cannabinoids with some membrane proteins, possibly including the receptor for ADP.

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