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Experimental study of the toxicity of arils from Blighia sapida (Sapindaceae) in relation to the poisoning of children of Katiola (Ivory Coast)

Foungbe, S.; Naho, Y.; Declume, C.

Annales Pharmaceutiques Francaises 44(6): 509-515

1986

ISSN/ISBN: 0003-4509
PMID: 3039897
Document Number: 268557
In May-June 1984, forty children died in Katiola (Cote-d' Ivoire) presumably after ingestion of unripe arillus from Blighia sapida (Sapindaceae). An experimental study on the rat indicate that toxicity of hypoglycin A contained in the arillus is raised by starvation and that daily ingestion of infratoxic doses produce a cumulative and delayed hypoglycemic effect that can be lethal. The ripe arillus, that contain less hyopoglycin A, could so produce this cumulative and delayed effect on starving children.

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